During which week should an RH negative mother receive RhoGAM?

• A. 24 Weeks
• B. 28 Weeks
• C. 30 Weeks
• D. 32 Weeks

Answer: (B)

The administration of RhoGAM, a medication containing Rh immunoglobulin, is crucial for an Rh-negative mother during pregnancy to prevent Rh incompatibility with her Rh-positive fetus. The standard recommendation is to give RhoGAM at 28 weeks of gestation. This timing is based on the understanding of when the risk of Rh sensitization is highest, helping to ensure that the mother's immune system does not produce antibodies against Rh-positive red blood cells.

At this point in the pregnancy, the fetal Rh status is often unknown, and the preventive measure aims to protect against potential sensitization during the latter stages of pregnancy and at delivery. The administration at 28 weeks allows for effective coverage in case of potential mixing of maternal and fetal blood.

Other weeks listed do not align with the recommended timing for administering RhoGAM. For instance, while administering RhoGAM at 24 weeks may seem close, it is generally considered too early for optimal preventive impact. The later options also exceed the standard guideline, as RhoGAM is typically administered no later than 28 weeks unless there are specific circumstances warranting a different timing. Therefore, the choice of 28 weeks is the correct and standard practice for administering RhoGAM.